Results of the use of Dermatol. Do you find that the product offers assistance without serious downside?

2 Answers

  • Anonymous
    1 decade ago
    Favorite Answer

    Originally published October 12 2006

    Acne medication associated with abnormal blood test results (press release)

    by NewsTarget

    Elevated cholesterol levels and liver enzyme levels appear to be more common than previously thought among patients taking the acne medication isoretinoin, including those who had normal blood test results before beginning therapy, according to a report in the August issue of Archives of Dermatology, one of the JAMA/Archives journals.

    Isoretinoin, commonly marketed as Accutane, is the most effective acne treatment currently available, according to background information in the article. As many as 89 percent of patients taking the medication achieve long-term remission from acne. Side effects include elevations in the levels of triglycerides, blood fats that can have an adverse effect on cardiovascular health; liver enzymes, the presence of which indicates liver disease or inflammation; and total blood cholesterol. According to the article, the Accutane package insert notes that 25 percent of patients develop elevated triglycerides and 15 percent elevated liver enzymes. Other studies have found elevated triglycerides in 5 to 18 percent and elevated total cholesterol in 6 to 32 percent of individuals taking the drug.

    Lee T. Zane, M.D., M.A.S., University of California, San Francisco, and colleagues assessed the frequency of abnormal laboratory tests in a population of 13,772 patients (aged 13 to 50 years, 51 percent male and 49 percent female) with acne who underwent isoretinoin therapy between 1995 and 2002. The researchers analyzed medical records for each patient before, during and after they took the medication, using information from laboratory tests of triglycerides; total cholesterol; liver transaminase (enzymes) levels; white blood cell (cells that fight infection) count; hemoglobin (which carries oxygen through the body) level; and platelet (involved in blood clotting) count.

    Patients taking isoretinoins had an increased incidence of elevated triglyceride, total cholesterol and liver enzyme levels, but not hemoglobin levels, white blood cell counts or platelet counts. Among patients with normal pretreatment laboratory tests, 44 percent developed high triglycerides, 31 percent high cholesterol and 11 percent high liver enzymes while taking the medication. "Moderate to severe abnormalities in triglyceride, total cholesterol and transaminase levels were generally transient and reversible," the authors write. "Among those subjects with such abnormalities who received posttreatment testing, the proportion returning to normal or grade 1 [slightly elevated] levels by the end of the posttreatment period was 92 percent for transaminase level, 80 percent for triglyceride level and 79 percent for total cholesterol level."

    "Our study did not examine adverse clinical outcomes and thus cannot estimate the ability of abnormal laboratory results to predict such outcomes," they conclude. "In clinical practice, laboratory abnormalities should be evaluated in the clinical context of the individual patient. Neither does the presence of a laboratory abnormality necessarily signal the presence of an adverse clinical outcome, nor does the absence of a laboratory abnormality preclude the possibility of an adverse clinical outcome." Still, patients with acne who develop substantially high triglyceride levels are at risk for high cholesterol and the metabolic syndrome, which in turn may increase the risk for coronary artery disease; further study is needed regarding these side effects, the authors write. (Arch Dermatol. 2006;142:1016-1022. Available pre-embargo to the media at

    Contact: Vanessa deGier 415-514-1592 JAMA and Archives Journals

  • 4 years ago

    >would taking this pastime make me a hypocrite? you seem to be professional-determination, provided that you're happy females may have chance-free abortions. would not be counted that you would under no circumstances have one your self; in case you help different females's determination to abort then you truly are professional-determination. So no, operating at an abortion medical institution does not make you a hypocrite. I do, regardless of the indisputable fact that, ask your self how your professional-determination perspectives mesh mutually with your faith. As a Christian, each and every thing I see interior the Bible - from the commandments now to not kill, to all the passages talking about how little ones are a blessing and how God shapes us and is conscious us interior the womb - would aspect out that abortion is a grievous crime in God's eyes and under no circumstances something that any one might want to do. i'm of the opinion that perspectives like yours - little ones are a blessing and that i'd under no circumstances abort, yet when different females opt for to abort their youthful ones i'm fantastic with that - to be truly contradictory in nature interior the first position. If there is any hypocrisy, it truly is the position it lies, that and with the actual undeniable truth that as a Christian you help killing unborn little ones. Sorry to be blunt and "judgy" right here, yet it truly is basically my opinion. you probably did ask. ; ) >would my own emotions be offensive to my co-workers and sufferers? Nope. there are countless professional-determination females who would under no circumstances in my opinion have an abortion. >might want to i hit upon a fashion to reconcile with my more desirable conservative relatives's abhorrence of the container in which i'd be operating? probable not. they are hostile to abortion and also you'd be in reality participating in assisting females have them. they are not likely to be in any respect satisfied about that. there's no spin you may placed on it that'll make it a lot less of a difficulty for them.

Still have questions? Get your answers by asking now.