How does ACE (angiotensin-converting-enzyme) know to interact w/ angiotensin 1 intead of angiotensinogen?

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  • 1 decade ago
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    Angiotensinogen is the inactive form of angiotensin. ACE cannot act on angiotensinogen most likely because of an incompatibility in the binding site of ACE. If you remember, enzymes are very specific for the substrate they act upon. Angiotensiongen probably has a section on it that needs to be cut off (cleaved) by the enzyme Renin before ACE can get to the correct part of it (now angiotensin after cleavage) and interact.

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