Myasthenia gravis is a serious autoimmune disorder in which the body produces antibodies to its own nicotinic?

Question

receptors. What do you propose would be the effect of this disease on skeletal muscle activity? One treatment for this disease involves inhibitors of cholinesterase (the enzyme that breaks down Ach in the synapse). Why would this help alleviate symptoms of myasthenia gravis? Explain??

Answer 1

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The disease results in muscle weakness from over stimulation of the remaining receptors. AChE inhibitors remove some of the excess ACh, thereby allowing normal release and removal of the transmitter, just on a smaller scale.