Why are populations native to an island vulnerable?

Question

In terms of evolution and reproduction ?

Answer 1

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populations native to an island are vulnerable because there is no gene flow (migration).

therefore genetic variation can be decreased significantly as organisms only reproduce with each other. There is no random mating which is important for genetic diversity.

This loss of genetic variation (i.e. important genes are unwittingly lost) renders populations exposed to disease and other agents of extinction.