Oral maintenance dose of Cefalexin?
t½ = 1 hour; Clearance = 4.3 mL/min/kg; F = 0.9
what is the ORAL maintenance dose (in mg) of cefalexin to achieve a steady-state plasma concentration (Css,av) of 5 mg/L for a 17 kg child. The dosage interval should be 6 hours (four times a day). Cefalexin is available as a 25 mg/mL paediatric mixture. The recommended dose must be in mg and be practical (Hint: to the nearest 25 mg).
Answer: Dose = 150 mg
formulas that i used but can't arrive at the exact answer:
MD=Css,av x CL x t / F
Css,av=F x DM/CL x t
THANK YOU! :)
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