Anonymous asked in Science & MathematicsBiology · 2 months ago

2,3-BPG and high altitudes?

Hi,When in high altitudes, why do we make 2,3-Bisphosphoglycerate rather than just hyperventilating ?

1 Answer

  • Anonymous
    2 months ago

    Wellsaheimeryou'saniggah - the reason is the reason, the benefit is the benefit.  Your teacher should aks you to differentiate your bonds, niggahz!!  The reason 'why?' is because an intermediate of glycolysis begins to pile up as the hypoxia (from elevation) cuts down the efficiency of Krebs and ETC.  That intermediate is converted into 2,3-BPG because of nothing more than a mass balance shift.  Go find a diagram of full glycolysis and look at step #6.

    The benefit of such a thing is that BPG bound to Hgb has the effect of lowering the oxygen binding affinity, shifting the curve to the right, resulting in more release of oxygen to the tissues.

    The balance between plasma O2 and inhaled air composition will determine the need for ventilation changes.

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